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Care During Chemotherapy and Beyond

TICE



Generic Name: BCG (Bacillus Calmette-Guerin)
Trade Names: TheraCys®, TICE® BCG

Drug Type:

TICE is a biologic response modifier. (For more detail, see "How TICE Works" section below).

What TICE Is Used For:

  • Bladder cancer
  • Immunization against tuberculosis

Note: If a drug has been approved for one use, physicians sometimes elect to use this same drug for other problems if they believe it might be helpful.
 
How TICE Is Given:

  • TICE is given by intravesicular infusion.  This means it is given directly into the bladder through a urinary catheter.  The urinary catheter is inserted through the urethra (the tube which carries urine from the bladder to the outside the body).  The TICE solution is injected into the catheter, which is then clamped.  Clamping the catheter allows the medication to remain in the bladder.  The patient is encouraged to roll from side to side and to lie on their backs to help the medication reach all areas of the bladder.  After a predetermined time (usually about 2 hours) the catheter is unclamped and the fluid is drained.  The catheter is then removed.
  • TICE treatment is given as an outpatient procedure.
  • The treatments are usually given on a weekly basis for 6 weeks followed by treatments once a month for 6 to 12 months. Your doctor will determine your exact treatment schedule and dose.

Side Effects of TICE:

Important things to remember about the side effects of TICE:

  • Most people do not experience all of the side effects listed.
  • Side effects are often predictable in terms of their onset and duration.
  • Side effects are almost always reversible and will go away after therapy is complete.
  • There are many options to minimize or prevent side effects.
  • There is no relationship between the presence or severity of side effects and the effectiveness of the medication.

The following side effects are common (occurring in greater than 30%) for patients having TICE treatments:

These are less common side effects (occurring in 10-29%) for patients receiving TICE vaccine:

  • Bladder irritation or infection

A rare, but potentially serious side effect of TICE is called systemic TICE reaction.  This systemic reaction to TICE can occur following exposure to TICE within one week of either biopsy, TUR(trans-urethral resection) surgery, or traumatic bladder catheterization.  Symptoms of a systemic TICE reaction include unexplained high fever lasting 24-48 hours or more, chills, confusion, dizziness or lightheadedness (symptoms of low blood pressure) or shortness of breath.  A systemic TICE reaction can cause pneumonitis, hepatitis, prostatitis, epididimal-orchitis, respiratory distress and other symptoms of sepsis (systemic infection).

Not all side effects are listed above, some that are rare (occurring in less than 10% of patients) are not listed here.  However, you should always inform your health care provider if you experience any unusual symptoms.

When To Contact Your Doctor or Health Care Provider:

Contact your healthcare provider immediately, day or night, if you should experience any of the following symptoms:

  • Shortness of breath
  • Confusion
  • Dizziness or lightheadedness

The following symptoms require medical attention, but are not an emergency.  Contact your health care provider within 24 hours of noticing any of the following:

  • Fever of 39.5(C (103(F) or higher within 24 hours.
  • Fever of 38.5(C (101(F) or higher after 48 hours.
  • Blood in the urine.
  • Extreme fatigue (unable to perform self care activities).
  • Fever, chills, malaise, flu-like symptoms, increased fatigue or an increase in urinary symptoms (such as burning or pain on urination) are not uncommon.  However, if these increase in severity, or last more than 48 hours let your doctor know.

Always inform your health care provider if you experience any unusual symptoms.

TICE Precautions:

  • Before starting TICE treatments, make sure you tell your doctor about any other medications you are taking (including over-the-counter drugs, vitamins, or herbal remedies).
  • TICE may be inadvisable in tuberculin positive individuals.
  • Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment.  Pregnancy category C (use in pregnancy only if benefit to mother outweighs risk to the fetus). 
  • To avoid transmission of TICE to others, for 6 hours after treatment patients should void (urinate) while seated to avoid splashing of urine.  Urine voided during this time should be disinfected with 2 cups of household bleach into the toilet water and letting it stand for 15-20 minutes before flushing.
  • Men having this treatment can pass on TICE during sex.  To protect your partner from coming into contact with TICE, you should not have sex for 48 hours after each treatment.  Use a condom if you have sex at other times during the treatment course and for six weeks after treatment has ended.
  • For both men and women: Do not conceive a child (get pregnant) while taking TICE treatments.  Barrier methods of contraception, such as condoms, are recommended.  Discuss with your doctor when you may safely become pregnant after therapy.
  • Do not breast-feed while taking TICE.

TICE Self Care Tips:

  • Limit fluid intake for 6-10 hrs before treatment and for 2 hours following installation of TICE, afterward resume normal fluid intake.
  • Avoid caffeine and alcohol on treatment days.  This is due to the diuretic and irritant properties of these substances.
  • Get plenty of rest.
  • Maintain good nutrition.
  • If you experience symptoms or side effects, be sure to discuss them with your health care team.  They can prescribe medications and/or offer other suggestions that are effective in managing such problems.

Monitoring and Testing While Taking TICE:

You will be monitored regularly by your doctor while you are receiving treatment with TICE. Your doctor will order blood tests and other tests as needed to monitor side effects and check your response to therapy. 

How TICE Works:

TICE is an inactivated form of the tuberculosis bacteria.  It works against cancer as a biologic response modifier. Biological response modifiers are substances that have no direct antitumor effect but are able to trigger the immune system to indirectly affect tumors.

TICE is thought to bring about an immune response in the bladder by triggering an inflammatory reaction in the bladder.  This reaction brings disease-fighting white blood cells and cytokines (proteins produced by one cell that influence the behavior of other cells) to the bladder.  The immune system cells then fight directly against the tumor cells.  The cytokine response changes the environment in the bladder that may inhibit future tumor growth and progression.

Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.