Chemocare.com

Care During Chemotherapy and Beyond

Eribulin



Generic Name: Eribulin (er i BUE lin)

Trade Name(s): Halaven®

Eribulin is the generic name for the trade name drug Halaven. In some cases, health care professionals may use the trade name Halaven when referring to the generic drug name eribulin.

Drug Type:

Eribulin is an anti-cancer ("antineoplastic" or "cytotoxic") chemotherapy drug. This medication is classified as a "­­­­­­­­­non-taxane microtubule inhibitor". (For more detail, see “How Eribulin Works” below)

What Eribulin Is Used For:

Eribulin is used for the treatment of patients with metastatic breast cancer.

Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.

How Eribulin Is Given:

  • Eribulin is given through a vein as an intravenous push or as intravenous infusion over 2 to 5 minutes.

The amount of eribulin that you will receive depends on many factors, including your height and weight, your general health or other health problems, and the type of cancer or condition you have. Your doctor will determine your exact dosage and schedule.

Side effects of Eribulin:

Important things to remember about the side effects of eribulin:

  • Most people will not experience all of the eribulin side effects listed.
  • Eribulin side effects are often predictable in terms of their onset, duration, and severity.
  • Eribulin side effects will improve after therapy is complete.
  • Eribulin side effects may be quite manageable. There are many options to minimize or prevent the side effects of eribulin.

The following side effects are common (occurring in greater than 30%) for patients taking eribulin:

  • Low blood counts. Your white and red blood cells may temporarily decrease. This can put you at increased risk for infection and/or anemia.
    • Nadir: (approximately 13 days; recovery approximately 8 days)

These are less common (occurring in 10-29%) side effects for patients receiving eribulin:

Not all side effects are listed above. Side effects that are rare -- occurring in less than about 10 percent of patients -- are not listed here. But you should always inform your health care provider if you experience any unusual symptoms.

When to Contact Your Doctor or Health Care Provider:

Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:

  • Fever of 100.4° F (38° C) or higher, chills (possible signs of infection)

The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any of the following:

  • Nausea (interferes with ability to eat and unrelieved with prescribed medication)
  • Vomiting (vomiting more than 4-5 times in a 24 hour period)
  • Diarrhea (4-6 episodes in a 24-hour period)
  • Unusual bleeding or bruising
  • Black or tarry stools, or blood in your stools
  • Blood in the urine
  • Pain or burning with urination
  • Extreme fatigue (unable to carry on self-care activities)
  • Mouth sores (painful redness, swelling or ulcers)

Always inform your health care provider if you experience any unusual symptoms.

Eribulin Precautions:

  • Before starting eribulin treatment, make sure you tell your doctor about any other medications you are taking (including prescription, over-the-counter, vitamins, herbal remedies, etc.). Do not take aspirin, products containing aspirin unless your doctor specifically permits this.
  • Do not receive any kind of immunization or vaccination without your doctor’s approval while taking eribulin. .
  • Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Eribulin may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus.)
  • For both men and women: Use contraceptives, and do not conceive a child (get pregnant) while taking eribulin. Barrier methods of contraception, such as condoms, are recommended.
  • Do not breast feed while taking eribulin.

 Eribulin Self-Care Tips:

  • Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
  • You may be at risk of infection so try to avoid crowds or people with colds, and report fever or any other signs of infection immediately to your health care provider.
  • Wash your hands often.
  • To help treat/prevent mouth sores, use a soft toothbrush, and rinse three times a day with 1 teaspoon of baking soda mixed with 8 ounces of water.
  • Keep your bowels moving. Your health care provider may prescribe a stool softener to help prevent constipation that may be caused by Erubulin.
  • Avoid contact sports or activities that could cause injury.
  • To reduce nausea, take anti-nausea medications as prescribed by your doctor, and eat small, frequent meals.
  • Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.
  • In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
  • Get plenty of rest.
  • Maintain good nutrition.
  • Remain active as you are able.  Gentle exercise is encouraged such as a daily walk.
  • If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other suggestions that are effective in managing such problems.

Monitoring and Testing While Taking Eribulin:

You will be checked regularly by your doctor while you are taking eribulin, to monitor side effects and check your response to therapy. Periodic blood work will be obtained to monitor your complete blood count (CBC) as well as the function of other organs (such as your kidneys and liver) will also be ordered by your doctor.  You may be asked to get ECG to monitor your heart’s rhythm if you have history of heart failure or very slow heartrate.  You will be assessed for peripheral neuropathy regularly.

How Eribulin Works:

Cancerous tumors are characterized by cell division, which is no longer controlled as it is in normal tissue.   "Normal" cells stop dividing when they come into contact with like cells, a mechanism known as contact inhibition.  Cancerous cells lose this ability.  Cancer cells no longer have the normal checks and balances in place that control and limit cell division.  The process of cell division, whether normal or cancerous cells, is through the cell cycle.  The cell cycle goes from the resting phase, through active growing phases, and then to mitosis (division).

The ability of chemotherapy to kill cancer cells depends on its ability to halt cell division.  Usually, the drugs work by damaging the RNA or DNA that tells the cell how to copy itself in division.  If the cells are unable to divide, they die.  The faster the cells are dividing, the more likely it is that chemotherapy will kill the cells, causing the tumor to shrink.  They also induce cell suicide (self-death or apoptosis).

Chemotherapy drugs that affect cells only when they are dividing are called cell-cycle specific.  Chemotherapy drugs that affect cells when they are at rest are called cell-cycle non-specific.  The scheduling of chemotherapy is set based on the type of cells, rate at which they divide, and the time at which a given drug is likely to be effective.  This is why chemotherapy is typically given in cycles.

Chemotherapy is most effective at killing cells that are rapidly dividing.  Unfortunately, chemotherapy does not know the difference between the cancerous cells and the normal cells. The "normal" cells will grow back and be healthy but in the meantime, side effects occur.  The "normal" cells most commonly affected by chemotherapy are the blood cells, the cells in the mouth, stomach and bowel, and the hair follicles; resulting in low blood counts, mouth sores, nausea, diarrhea, and/or hair loss.  Different drugs may affect different parts of the body.

Antimicrotubule agents (such as eribulin), attack cells during a certain phase of division and so are considered cell-cycle specific.  Erubulin interferes with the microtubule structures within the cell.  Microtubules are part of the cell's apparatus for dividing and reproducing itself.  Inhibition of these microtubule structures ultimately results in cell death. 

Note: We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in this website is meant to be helpful and educational, but is not a substitute for medical advice.