Care During Chemotherapy and Beyond
Trade Name: Aromasin
Aromasin ® is the trade name for the generic drug
exemestane. In some cases, health care professionals may use the trade name Aromasin® when referring to the generic drug name exemestane.
Exemestane is a hormone therapy. It is classified as an "aromatase inhibitor."
(For more detail see "How Exemestane Works" below).
What Exemestane Is Used For:
- Exemestane is used to treat advanced breast cancer in post-menopausal women.
Note: If a drug has been approved for one use, physicians may elect to use
this same drug for other problems if they believe it may be helpful.
How Exemestane Is Given:
- Exemestane is a pill, taken by mouth.
- You should take exemestane at about the same time each day. Take with food.
If you miss a dose, do not take a double dose the next day.
- You should not stop taking exemestane without discussing with your physician.
- The amount of exemestane you receive depends on many factors. Your doctor
will determine your dose and how long you sill be taking exemestane.
Side Effects of Exemestane:
Important things to remember about the side effects of exemestane:
- Most people do not experience all of the side effects listed.
- Side effects are often predictable in terms of their onset and duration.
- Side effects are almost always reversible and will go away after treatment is complete.
- There are many options to help minimize or prevent side effects.
- There is no relationship between the presence or severity of side effects and the
effectiveness of the medication.
The following side effects are common (occurring in greater than 30%) for patients
These side effects are less common side effects (occurring in about 10-29%) of patients
Not all side effects are listed above. Some that are rare (occurring in less than
10% of patients) are not listed here. However, you should always inform your
health care provider if you experience any unusual symptoms.
When To Contact Your Doctor or Health Care Provider:
Contact your health care provider immediately, day or night, if you should experience
any of the following symptoms:
- Shortness of breath or difficulty breathing
- Having thoughts or feeling like you may want to harm yourself or others
The following symptoms require medical attention, but are not an emergency.
Contact your health care provider within 24 hours of noticing any of the
- Vaginal bleeding (similar to a period)
Always inform your health care provider if you experience any unusual symptoms.
- Before starting Exemestane treatment, make sure you tell your doctor about any other
medications you are taking (including prescription, over-the-counter, vitamins,
herbal remedies, etc.).
- Inform your health care professional if you are pregnant or may be pregnant prior
to starting this treatment. Pregnancy category D (Exemestane may be hazardous
to the fetus. Women who are pregnant or become pregnant must be advised of
the potential hazard to the fetus).
- For both men and women: Do not conceive a child (get pregnant) while taking Exemestane.
Barrier methods of contraception, such as condoms, are recommended. Discuss with
your doctor when you may safely become pregnant or conceive a child after therapy.
- Do not breast feed while taking Exemestane.
Exemestane Self Care Tips:
- Take Exemestane after a meal; at about the same time every day.
- Exemestane causes little nausea. But if you should experience nausea, take
anti-nausea medications as prescribed by your doctor, and eat small frequent meals.
Sucking on lozenges and chewing gum may also help.
- In general, drinking alcoholic beverages should be kept to a minimum or avoided
completely. You should discuss this with your doctor.
- If you are experiencing hot flashes, wearing light clothing, staying in a cool environment,
and putting cool cloths on your head may reduce symptoms. Consult you health care
provider if these worsen, or become intolerable.
- Acetaminophen or ibuprophen may help relieve discomfort generalized aches and
pains. However, be sure to talk with your doctor before taking it.
- Get plenty of rest.
- Maintain good nutrition.
- If you experience symptoms or side effects, be sure to discuss them with your health
care team. They can prescribe medications and/or offer other suggestions that
are effective in managing such problems.
Monitoring and Testing While Taking Exemestane:
You will be monitored regularly by your doctor while you are taking exemestane,
but no special tests are required.
How Exemestane Works:
Hormones are chemical substances that are produced by glands in the body, which
enter the bloodstream and cause effects in other tissues. For example, the
hormone testosterone made in the testicles and is responsible for male characteristics
such as deepening voice and increased body hair. The use of hormone therapy
to treat cancer is based on the observation that receptors for specific hormones
that are needed for cell growth are on the surface of some tumor cells. Hormone
therapies work by stopping the production of a certain hormone, blocking hormone
receptors, or substituting chemically similar agents for the active hormone, which
cannot be used by the tumor cell. The different types of hormone therapies
are categorized by their function and/or the type of hormone that is affected.
Exemestane is an aromatase inhibitor. This means it blocks the enzyme aromatase
(found in the body's muscle, skin, breast and fat), which is used to convert androgens
(hormones produced by the adrenal glands) into estrogen. In the absence of estrogen,
tumors dependent on this hormone for growth will shrink.
Note: We strongly encourage you to talk with your health care professional
about your specific medical condition and treatments. The information contained
in this website is meant to be helpful and educational, but is not a substitute
for medical advice.
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