Care During Chemotherapy and Beyond
The Immune System: Information about Lymphocytes, Dendritic Cells, Macrophages, and White Blood Cells
The Immune system is a complex network of cells (such as lymphocytes) and organs
that work together to defend the body against foreign substances (antigens) such
as bacteria, a virus or tumor cell. When the body discovers such a substance
several kinds of cells go into action in what is called an immune response.
Below is a description of some of the cells that are part of the immune system.
Lymphocytes are one of the main types of immune cells. Lymphocytes are
divided mainly into B and T cells.
- B lymphocytes produce antibodies - proteins (gamma globulins) that recognize
foreign substances (antigen) and attach themselves to them. B lymphocytes
(or B cells) are each programmed to make one specific antibody.
When a B cell comes across its triggering antigen it gives rise to many large cells
known as plasma cells. Each plasma cell is essentially a factory for producing
antibody. An antibody matches an antigen much like a key matches a lock.
Whenever the antibody and antigen interlock, the antibody marks the antigen for
destruction. B lymphocytes are powerless to penetrate the cell so the job
of attacking these target cells is left to T lymphocytes.
- T lymphocytes are cells that are programmed to recognize, respond to and
remember antigens. T lymphocytes (or T cells) contribute to the immune defenses
in two major ways. Some direct and regulate the immune responses. When stimulated
by the antigenic material presented by the macrophages, the T cells make lymphokines
that signal other cells. Other T lymphocytes are able to destroy targeted
cells on direct contact.
Macrophages are the body's first line of defense and have many roles. A macrophage
is the first cell to recognize and engulf foreign substances (antigens). Macrophages
break down these substances and present the smaller proteins to the T lymphocytes.
(T cells are programmed to recognize, respond to and remember antigens). Macrophages
also produce substances called cytokines that help to regulate the activity of lymphocytes.
Dendritic cells are known as the most efficient antigen-presenting cell type with
the ability to interact with T cells and initiate an immune response. Dendritic
cells are receiving increasing scientific and clinical interest due to their key
role in the immune response and potential use with tumor vaccines.
White Blood Cells
There are different types of white blood cells that are part of the immune response.
Neutrophils or granulocytes are the most common immune cells in the body.
With an infection, their number increases rapidly. They are the major components
of pus and are found around most common inflammations. Their job is to eat
and destroy foreign material. Basophils and eosinophils are white blood cells
that contain large granules inside the cell. They interact with certain foreign
materials. Their increased activity may lead to an allergic reaction.
The immune response is a coordinated effort. All of the immune cells work
together, so they need to communicate with each other. They do this by secreting increased
levels of a special protein molecule called cytokines that act on other cells.
There are many different cytokines. Examples of these are interleukins, interferons,
tumor necrosis factors, and colony-stimulating factors. Some
immunotherapy treatment strategies involve giving larger amounts of these
proteins by an injection or infusion. This is done in the hope of stimulating
the cells of the immune system to act more effectively or to make the tumor cells
more recognizable to the immune system.
Caution: There are people who promote unproven therapies
as immune system boosters. Be careful when evaluating these claims.
The following are types of immunotherapies that are commonly and legitimately used
in traditional and scientific medical practice.
More Chemotherapy Information:
Protocols - How Chemotherapy Works
How Chemotherapy Is Given
How Doctors Decide Which Chemotherapy Drugs To Give
How Long Chemotherapy Is Given
How To Tell If Chemotherapy Is Working
Cancer Cells & Chemotherapy
Short & Long Term Side Effects of Chemotherapy
Cancer Clinical Trials
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