Chemocare.com
Care During Chemotherapy and Beyond
Generic name:
Bosutinib
Bosulif® is the trade for the generic chemotherapy drug Bosutinib. In some cases, health care professionals may use the generic name Bosutinib
when referring to the trade name Bosulif®.
Drug type:
Bosulif® is a targeted therapy. It is an oral receptor tyrosine kinase inhibitor - (For more detail, see "How this drug works," below.)
What This Drug Is Used For:
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For the treatment of adult Philadelphia chromosome-positive chronic myelogenous leukemia.
Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful.
How This Drug Is Given:
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Bosulif® is a pill, taken by mouth. Take with food.
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Take Bosulif® exactly as prescribed, even if you are feeling better.
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Swallow Bosulif® capsules whole. Do not chew, crush or break.
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Do not change your dose or stop Bosulif® unless your health care provider tells you to.
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If you miss a dose, take it as soon as you remember. If it is too close to your next dose (within 12 hours), just take your next dose at your regular
time.
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Do not take more 2 doses or extra doses of Bosulif® at the same time. Call your health care provider right away if you take too much.
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Avoid grapefruit, grapefruit juice, and supplements that contain grapefruit extract while taking Bosulif®. Grapefruit products may increase
the amount of Bosulif®.
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The amount of Bosulif® that you will receive depends on many factors, your general health or other health problems, and the type of cancer
or condition being treated.
Side Effects:
Important things to remember about the side effects of Bosulif®:
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Most people do not experience all of the side effects listed.
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Side effects are often predictable in terms of their onset and duration.
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There are many options to help minimize or prevent side effects.
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There is no relationship between the presence or severity of side effects and the effectiveness of the medication.
The following side effects are common (occurring in greater than 30%) for patients taking
Bosulif®:
These side effects are less common side effects (occurring in about 10-29%) of patients receiving
Bosulif®:
Not all side effects are listed above. Some that are rare (occurring in less than 10% of patients) are not listed here. However, you should always
inform your health care provider if you experience any unusual symptoms.
When to contact your doctor or health care provider:
Contact your health care provider immediately, day or night, if you should experience any of the following symptoms:
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Fever of 100.4° F (38°C or higher, chills)
Always inform your health care provider if you experience any unusual symptoms.
The following symptoms require medical attention, but are not an emergency. Contact your health care provider within 24 hours of noticing any
of the following:
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Diarrhea (4-6 episodes in a 24-hour period)
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Nausea (interferes with ability to eat and unrelieved with prescribed medication).
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Vomiting (vomiting more than 4-5 times in a 24 hour period)
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Unable to eat or drink for 24 hours or have signs of dehydration: tiredness, thirst, dry mouth, dark and decrease amount of urine, or dizziness
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Skin or the whites of your eyes turn yellow
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Urine turns dark or brown (tea color)
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Decreased appetite
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Pain on the right side of your stomach
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Bleed or bruise more easily than normal
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Respiratory tract infection
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Headache, back pain or joint pain
· Skin changes (rash, acne, itching, blisters, peeling, redness or swelling)
Always inform your health care provider if you experience any unusual symptoms.
Precautions:
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Bosulif® may interact with many types of medications. Before starting Bosulif® treatment, make sure you tell your doctor about any other medications you are taking (including prescription,
over-the-counter, vitamins, herbal remedies, etc.).
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Do not receive any kind of immunization or vaccination without your doctor's approval while taking Bosulif®.
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Inform your health care professional if you are pregnant or may be pregnant prior to starting this treatment. Pregnancy category D (Bosulif ® may be hazardous to the fetus. Women who are pregnant or become pregnant must be advised of the potential hazard to the fetus).
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For both men and women: Do not conceive a child (get pregnant) while taking Bosulif®. Barrier methods of contraception, such as condoms, are
recommended during and at least 30 days after completing treatment. Discuss with your doctor when you may safely become pregnant or conceive a child
after therapy.
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Do not breast feed while taking this medication.
Self-Care Tips:
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Drink at least two to three quarts of fluid every 24 hours, unless you are instructed otherwise.
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If you should experience nausea, take anti-nausea medications as prescribed by your doctor, and eat small frequent meals. Sucking on lozenges and
chewing gum may also help.
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Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.
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In general, drinking alcoholic beverages should be kept to a minimum or avoided completely. You should discuss this with your doctor.
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Get plenty of rest.
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Maintain good nutrition.
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If you experience symptoms or side effects, be sure to discuss them with your health care team. They can prescribe medications and/or offer other
suggestions that are effective in managing such problems.
Monitoring and Testing:
You will be checked regularly by your health care professional while you are taking Bosulif®. Testing may include blood work that checks blood
counts and liver functions.
How This Drug Works:
Targeted therapy is the result of about 100 years of research dedicated to understanding the differences between cancer cells and normal cells. To date,
cancer treatment has focused primarily on killing rapidly dividing cells because one feature of cancer cells is that they divide rapidly. Unfortunately,
some of our normal cells divide rapidly too, causing multiple side effects.
Targeted therapy is about identifying other features of cancer cells. Scientists look for specific differences in the cancer cells and the normal cells.
This information is used to create a targeted therapy to attack the cancer cells without damaging the normal cells, thus leading to fewer side effects.
Each type of targeted therapy works a little bit differently but all interfere with the ability of the cancer cell to grow, divide, repair and/or
communicate with other cells.
There are different types of targeted therapies, defined in three broad categories. Some targeted therapies focus on the internal components and function
of the cancer cell. The targeted therapies use small molecules that can get into the cell and disrupt the function of the cells, causing them to die. There
are several types of targeted therapy that focus on the inner parts of the cells. Other targeted therapies target receptors that are on the outside of the
cell. Therapies that target receptors are also known as monoclonal antibodies. Antiangiogenesis inhibitors target the blood vessels that supply oxygen to
the cells, ultimately causing the cells to starve.
Bosulif® is a targeted therapy that targets and binds to the tyrosine kinase receptors and inhibits BCR-ABL kinase and SRC kinase receptors
within the cell. By binding to these receptors Bosulif® blocks an important pathway that promotes cell division.
Research continues to identify which cancers may be best treated with targeted therapies and to identify additional targets for more types of cancer.
Note:
We strongly encourage you to talk with your health care professional about your specific medical condition and treatments. The information contained in
this website is meant to be helpful and educational, but is not a substitute for medical advice.
Chemocare.com is designed to provide the latest information about chemotherapy to patients and their families, caregivers and friends. For information about the 4th Angel Mentoring Program visit www.4thangel.org