Care During Chemotherapy and Beyond
Generic Name: Dexamethasone
Other Brand Names: Dexasone,
Diodex, Hexadrol, Maxidex
Other Names: Dexamethasone
Sodium Phosphate, Dexamethasone Acetate
Decadron has many uses in the treatment of cancer. It is classified as a glucocorticosteroid.
(For more detail, see "How Decadron Works" section below).
What Decadron Is Used For:
- As an anti-inflammatory medication. Decadron relieves inflammation in
various parts of the body. It is used specifically to decrease swelling (edema),
associated with tumors of the spine and brain, and to treat eye inflammation.
- To treat or prevent allergic reactions.
- As treatment of certain kinds of autoimmune diseases, skin conditions, asthma and
other lung conditions.
- As treatment for a variety of cancers, such as leukemia, lymphoma, and multiple
- To treat nausea and vomiting associated with some chemotherapy drugs.
- Used to stimulate appetite in cancer patients with severe appetite problems.
- Also used to replace steroids in conditions of adrenal insufficiency (low production
of needed steroids produced by the adrenal glands).
Note: If a drug has been approved
for one use, physicians sometimes elect to use this same drug for other problems
if they believe it might be helpful.
How Decadron Is Given:
- Decadron may be given to you in many forms. In a pill form, it is available in a
variety of tablet sizes. If you are on a daily dose of Decadron (usually less
than 10 mg), and you miss a dose, take the dose as soon as you remember. If you
are on high doses of Decadron (20 mg or 40 mg per day for 4 days out of the month),
and you miss your dose, contact your healthcare provider. You may be instructed
to repeat the missed dose, and continue the medication.
- Take pills with food or after meals
- Decadron may also be given by infusion into a vein (intravenously or IV)
- Decadron eye drops are given to treat or prevent many eye conditions. The eye drops
are most commonly given to patients with leukemia or lymphoma, to prevent inflammation
of the eyes (conjunctivitis), if you are receiving high dose chemotherapy (usually
Cytarabine [Ara-C]). The eye drops are given every six hours, in both eyes, and
for at least 48 hours after the chemotherapy has completed. Do not stop taking
these eye drops unless directed by your healthcare provider.
- You may be given Decadron as a lotion (topical) to treat skin disorders.
- The amount of Decadron you will receive depends on many factors, including your
general health or other health problems, and the reason you are receiving Decadron.
Your doctor will determine your dosage and schedule.
Important things to remember about Decadron side effects:
- Most people do not experience all of the Decadron side effects listed.
- Decadron side effects are often predictable in terms of their onset and duration.
- Decadron side effects are almost always reversible and will go away after treatment
- There are many options to help minimize or prevent Decadron side effects.
The following Decadron side effects are common (occurring in greater than 30%) for
patients taking Decadron:
The following are less common Decadron side effects (occurring in >10%) for patients
- Mood swings
- Cataracts and bone thinning (with long-term use)
This list includes common and less common side effects for individuals taking Decadron.
Decadron side effects that are very rare, occurring in less than 10% of patients,
are not listed here. However, you should always inform your health care provider
if you experience any unusual symptoms.
When to contact your doctor or health care provider:
Contact your health care provider immediately, day or night, if you should experience
any of the following symptoms:
- Fever of 100.4° F (38° C), chills (possible signs of infection)
- If you feel an irregular or fast heartbeat, shortness of breath, or chest or jaw
pain, seek emergency help and notify your healthcare provider
- If you become suddenly confused
The following symptoms require medical attention, but are not emergency situations.
Contact your health care provider within 24 hours of noticing any of the following:
- Extreme fatigue (unable to carry on self-care activities)
- Any unusual bleeding or bruising
- Black or tarry stools, or blood in your stools or urine
- Nausea (interferes with ability to eat and unrelieved with prescribed medications)
- Vomiting (vomiting more than 4-5 times in a 24-hour period)
- Dizziness or lightheadedness, feeling faint.
- Persistent headache
- Severe hot flashes or mood swings
- Inability to sleep (insomnia)
- Severe skeletal (bone) pain
- Difficult or painful urination; increased urination, or severe thirst
- Changes in vision, blurred vision, eye pain, enlarged pupils, discharge
- Any new rashes or changes in your skin
- Swelling of the feet or ankles. Sudden weight gain (greater than 3 pounds
- Swelling, redness and/or pain in one leg or arm and not the other
Always inform your health care provider if you experience any unusual symptoms.
- Before starting Decadron treatment, make sure you tell your doctor about any other
medications you are taking (including prescription, over-the-counter, vitamins,
herbal remedies, etc.). Do not take aspirin, or products containing aspirin unless your doctor specifically permits this.
- Do not receive any kind of immunization or vaccination without your doctor's approval
while taking Decadron.
- If you have been on Decadron pills daily, for a long period of time, serious side
effects may occur if you discontinue the medication abruptly. Do not stop taking
Decadron unless directed by your healthcare provider. Do not change the dose of
Decadron on your own.
- Inform your health care professional if you are pregnant or may be pregnant prior
to starting this treatment. Pregnancy category C (use in pregnancy only when
benefit to the mother outweighs risk to the fetus).
- For both men and women: Do not conceive a child (get pregnant) while taking Decadron.
Barrier methods of contraception, such as condoms, are recommended. Discuss with
your doctor when you may safely become pregnant or conceive a child after therapy.
- Do not breast feed while taking Decadron.
- If you are on Decadron for a long period of time, you may be more susceptible to
infection. Wash your hands well, and report any symptoms of infection to your healthcare
provider if noted.
- If you are given eye drops or eye ointment: You may be more sensitive to the light.
Wearing sunglasses may help. It is normal to notice a little blurriness for a short
time after the drops or ointment are placed in your eyes. Notify your healthcare
provider with any changes in vision, blurriness, or eye pain.
- If you are given eye drops or eye ointment: Ask your healthcare provider if you
may wear contact lenses. Contact lenses may absorb the medication for at least 15
minutes. Wash your hands well before putting eye drops, to decrease the chance of
a bacterial infection in your eyes.
- If you are Decadron as a lotion (topical) to treat skin disorders: Do not apply
to open areas of skin, or if you have open or weeping sores. Topical Decadron should
not be used for a long time. Discuss this with your healthcare provider.
- Take Decadron with food to lessen an upset stomach. Also take Decadron early on
in the day (before 12:00 noon, if possible), so you will be able to sleep better
- If you have diabetes, Decadron may increase your blood sugar levels. You may
need more frequent monitoring.
- Drink 2 to 3 quarts of fluid every 24 hours, unless you were told to restrict your
fluid intake, and maintain good nutrition.
- Avoid sun exposure. Wear SPF 15 (or higher) sun block and protective clothing.
- To reduce nausea, take anti-nausea medications as prescribed by your doctor, and
eat small, frequent meals.
- In general, drinking alcoholic beverages should be avoided. You should also
limit caffeine intake (colas, tea, coffee and chocolate, especially). These beverages
may irritate your stomach.
- If you experience symptoms or side effects, especially if severe, be sure to discuss
them with your health care team. They can prescribe medications and/or offer
other suggestions that are effective in managing such problems.
Monitoring and Testing:
You will be checked regularly by your health care professional while you are taking
Decadron, to monitor side effects and check your response to therapy. Periodic
blood work to monitor your complete blood count (CBC) as well as the function of
other organs (such as your kidneys and liver) will also be ordered by your doctor.
How Decadron Works:
Corticosteroids are naturally produced by the adrenal gland in the body. Corticosteroids
influence the functioning of most of the body's systems (heart, immune, muscles
and bones, endocrine and nervous system). They exert a wide array of effects
including effects on the metabolism of carbohydrates, protein and fats. They
help to maintain balance of fluids and electrolytes.
Decadron is classified as a corticosteroid (more precisely a glucocorticosteroid),
and has many uses in the treatment of cancer.
One way that it works is to decrease inflammation (swelling). It does this
by preventing infection- fighting white blood cells (polymorphonuclear leukocytes)
from traveling to the area of swelling in your body. (This is why you are more prone
to infection while taking steroids). Taking advantage of the anti-inflammatory
properties of the medication, corticosteroids are used to decrease the swelling
around tumors. For example, by decreasing swelling around tumors in the spine,
brain, or bone, it can decrease the pressure of the tumor on nerve endings and relieve
pain or other symptoms caused by the pressing tumor.
Another way Decadron works is by altering the body's normal immune system responses.
Corticosteroids are used to treat certain conditions that affect the immune system
such as aplastic anemia (AA), Immune Thrombocytopenia Purpura (ITP), Thrombotic
Thrombocytopenia Purpura (TTP), or hemolytic anemia.
In addition, it is thought that corticosteroids may help in the treatment of patients
with blood disorders, such as multiple myeloma. Corticosteroids may work by causing
programmed cell death (apoptosis) of certain cells, which may help to fight your
Decadron is also used in the short-term treatment of nausea caused by chemotherapy.
How it does this is not fully understood. It also has been used to stimulate
appetite for patients with severe appetite problems.
Corticosteroids are used to replace steroids in conditions of adrenal insufficiency
(low production of needed steroids produced by the adrenal glands).
Note: We strongly encourage you
to talk with your health care professional about your specific medical condition
and treatments. The information contained in this website is meant to be helpful
and educational, but is not a substitute for medical advice.
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