Care During Chemotherapy and Beyond
Generic Name: Lenalidomide
Revlimid is classified as
an "immunomodulatory agent," and an "antiangiogenic agent" (for more detail,
see "How Revlimid Works" section below.)
What Revlimid Is Used For:
- Treatment of Multiple Myeloma
- Treatment of transfusion-dependent myelodysplastic syndrome (MDS) patients with
deletion 5q cytogenetic abnormality with or without additional cytogenetic abnormalities.
- Treatment of Mantle Cell Lymphoma (MCL)
Note: If a drug has been approved for one use, physicians may elect to use this
same drug for other problems if they believe it may be helpful.
How Revlimid Is Given:
- Revlimid is taken as capsules by mouth. Swallow whole with water. Do not break,
chew, or open capsules.
- If you miss a dose of Revlimid, take it as soon as you remember that day.
If you miss taking your dose for the entire day, go back to taking your regular
dose the next day. Do not take 2 doses at the same time.
- Store Revlimid at room temperature, 59o to 86oF (15o
to 30o C).
- In order to receive Revlimid, there are strict guidelines that you must follow.
You will be required to participate in a special program called the "RevAssistsm
- Your doctor will determine your exact dosage and schedule. Dosage may be adjusted
based on your blood count results.
Important things to remember about the side effects of Revlimid:
- You will not get all of the side effects mentioned below.
- Side effects are often predictable in terms of their onset, duration, and severity.
- Side effects are almost always reversible and will go away after therapy is complete.
- Side effects are quite manageable. There are many options to minimize or prevent
The following side effects are common (occurring in greater than 30%) for patients
- Low blood counts . Your white blood
cells and platelets may temporarily decrease. This can put you at increased risk
for infection and/or bleeding. Blood counts are monitored closely and dose
adjustments may be necessary.
- Fatigue, tiredness
These are less common side effects for patients receiving Revlimid:
A rare, but serious side effect of Revlimid is blood clots, including deep
vein thrombosis (DVT) and pulmonary embolus (PE). You should seek emergency
help and notify your health care provider immediately if you develop sudden chest
pain and shortness of breath. Notify your health care provider within 24 hours
if you notice leg or arm swelling, redness, pain and/or skin warm to touch (signs
and symptoms of possible blood clot)..
Not all side effects are listed above. Some that are rare (occurring
in less than 10% of patients) are not listed here. However, you should always inform
your health care provider if you experience any unusual symptoms.
When to contact your doctor or health care provider:
Seek emergency help immediately and notify your health care provider,
it you experience the following symptoms:
- Sudden chest pain and shortness of breath.
Contact your health care provider immediately, day or night, if you should experience
any of the following symptoms:
- Fever of 100.4° F (38° C) or higher, chills (possible signs of infection)
The following symptoms require medical attention, but are not an emergency. Contact
your health care provider within 24 hours of noticing any of the following:
- Unusual bleeding or bruising
- Black or tarry stools, or blood in your stools.
- Blood in the urine.
- Diarrhea (4-6 episodes in a 24-hour period).
- Nausea (interferes with ability to eat and unrelieved with prescribed medication).
- Extreme fatigue (unable to carry on self-care activities).
- Leg or arm swelling, redness, pain and/or warm to touch.
Always inform your health care provider if you experience any unusual symptoms.
- Before starting Revlimid treatment, make sure you tell your doctor about any
other medications you are taking (including prescription, over-the-counter, vitamins,
herbal remedies, etc.).
- Do not receive any kind of immunization or vaccination without your doctor’s approval
while taking Revlimid.
- Revlimid is similar to the medication thalidomide a medication known to cause severe,
life-threatening birth defects. Pregnancy category X (Revlimid may cause fetal harm
when given to a pregnant woman. Revlimid must not be given to a pregnant woman or
a woman who intends to become pregnant. If a woman becomes pregnant while taking
Revlimid, the medication must be stopped immediately and the woman given appropriate
- Women of childbearing potential will be treated only if they are able to comply
with conditions of the RevAssistSM program. Two forms of effective
contraception are required beginning 4 weeks prior to, during, and for 4 weeks after
therapy and during therapy interruptions.
- Males (even those vasectomized) must use a latex condom during any sexual contact
with women of childbearing age. Risk to the fetus from semen of male patients
- Do not breast feed while taking Revlimid.
- Drink at least two to three quarts of fluid every 24 hours, unless you are instructed
- You may be at risk of infection so try to avoid crowds or people with colds, and
report fever or any other signs of infection immediately to your health care provider.
- Wash your hands often.
- Use an electric razor and a soft toothbrush to minimize bleeding.
- Avoid contact sports or activities that could cause injury.
- To reduce nausea, take anti-nausea medications as prescribed by your doctor, and
eat small, frequent meals.
- Avoid sun exposure. Wear SPF 15 (or higher) sunblock and protective clothing.
- In general, drinking alcoholic beverages should be kept to a minimum or avoided
completely. You should discuss this with your doctor.
- Get plenty of rest.
- Maintain good nutrition.
- If you experience symptoms or side effects, be sure to discuss them with your health
care team. They can prescribe medications and/or offer other suggestions that are
effective in managing such problems.
Monitoring and Testing:
You will be checked regularly by your doctor while you are taking Revlimid, to monitor
side effects and check your response to therapy. Periodic blood work will be obtained
to monitor your complete blood count (CBC) as well as the function of other organs
(such as your kidneys and liver) will also be ordered by your doctor. For females
of child-bearing potential (intact uterus, menstrual period within 24 months) a
negative pregnancy test may be required monthly before the next month's prescription
for Revlimid is given.
How Revlimid Works:
Revlimid's exact mechanism of action on cancer cells is not clear. It may
act by inhibiting the growth of new blood vessels (angiogenesis) in tumors, enhancing
the status of the immune system, or decreasing cytokine and growth factor production.
In normal tissue, new blood vessels are formed during tissue growth
and repair (i.e. a healing wound), and during the development of baby during pregnancy.
Blood vessels carry oxygen and nutrients to tissue that are necessary for growth
and survival. In cancer, tumors need blood vessels in order to grow and spread.
Through a complex process, endothelial cells (which line the blood vessels) are
able to divide and grow and create new blood vessels. This process is called
angiogenesis and it occurs in both healthy tissue and in cancerous tissue.
Additionally, Revlimid is known to have various effects on the immune system (immunomodulatory
agent), which may contribute to its therapeutic effect. Revlimid may also alter
the production and activity of cytokines (growth factors) involved in the growth
and survival of certain cancer cells. There may be an effect on the genes
that direct the cell's growth and activity particularly those associated with cytokines
(growth factors), apoptosis (cell death), and metabolism.
Note: We strongly encourage you to talk with your health care professional
about your specific medical condition and treatments. The information contained
in this website is meant to be helpful and educational, but is not a substitute
for medical advice.
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